Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content.Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid generation by activated human 15-1 shampoo primary MCs in culture.Silencing of ATGL in MCs by